理聘网-职位详情页，Bioinformatician 博士后（Sho /吴炜祥课题组）(J10219)

课题组长介绍： Sho 毕业于冷泉港实验室，获得生物科学博士学位。2018 年，他建立了自己的独立实验室，在新加坡基因组研究所研究表观转录组学。2020 年，于深圳湾实验室担任特聘研究员。相关研究成果发表在 Nature Communications、Nucleic Acids Research、Genes & Development、PLoS Computational Biology、Cell 和 Nature Biotechnology 等期刊上。 Sho Goh 课题组通过开发新技术对 RNA 修饰进行测序，以及在功能上表征与 RNA 修饰相互作用并代谢 RNA 修饰的新型表观转录因子，研究 RNA 修饰如何调节基因表达和细胞过程。表观转录调控缺陷会导致多种疾病，确定这些缺陷背后的机制基础对于开发有效的基于表观转录的治疗策略至关重要。 Sho graduated from Cold Spring Harbor Laboratory with a Ph.D. in Biological Science. In 2018, he established his own independent laboratory, studying epitranscriptomics at the Genome Institute of Singapore. In 2020, he moved his laboratory to Shenzhen Bay Laboratory where he took on the role of tenure-track assistant professor. His work has been published in journals such as Nature Communications, Nucleic Acids Research, Genes & Development, PLoS Computational Biology, Cell and Nature Biotechnology. The Sho Goh lab studies how RNA modifications regulate gene expression and cellular processes by developing new technologies to sequence RNA modifications and functionally characterizing novel epitranscriptomic factors that interact with and metabolize RNA modifications. Defects in epitranscriptomic regulation cause a variety of diseases and determining the mechanistic basis that underlie these defects will be crucial for developing effective epitranscriptomic-based therapeutic strategies. 工作内容： 研究 RNA 修饰如何调节基因表达和细胞过程，以及这最终如何影响各种人类疾病的进展，具体包括： 1.开发新算法，利用第三代测序技术对多个高分辨率RNA修饰进行测序（多表观转录组学）； 2.研究各种独特的mRNA修饰之间的功能相互作用，以及这些相互作用在表观转录组学上如何促进人类发育和疾病。 The lab investigates how RNA modifications regulate gene expression and cellular processes, and how this eventually impacts the progression of various human disorders. The bioinformatician will take on projects with the following goals: 1.Develop new algorithms to sequence multiple high-resolution RNA modifications using third-generation sequencing technologies (Multi-epitranscriptomics); 2.Study the functional interactions between various unique mRNA modifications and how these interactions contribute to human development and disorders. 岗位要求： 1.强大的生物信息学背景，获得生物信息学或分子生物学学士/硕士/博士学位； 2.对表观转录组学和 RNA 生物学研究感兴趣； 3.积极性高，能够独立完成多个项目； 4.需要具备流利的英语书写和口语能力。 1.Strong bioinformatics background, with Bachelor's degree or above in Bioinformatics or Molecular Biology; 2.Interest in pursuing research in epitranscriptomics and RNA biology; 3.Highly motivated and able to work independently on multiple projects; 4.Fluency in written and spoken English is required. 条件待遇： 1.条件待遇：薪酬将与资历和经验相匹配，本科/硕士年薪为12-16万元人民币，博士为35-39万元人民币；初始任期为三年。经双方同意，可以续约； 2.基本保障：按照深圳市缴费比例上限缴纳五险一金，享受国家法定节假日、带薪年休假等假期；享受深圳湾实验室就餐补贴、节日慰问等福利； 3.特色福利：员工年度健康体检、补充医疗保险、免费班车、员工活动、节日慰问等； 4.科研环境：提供国际水准的研究条件和工作环境，包括充足的研究经费，尖端的技术支撑平台，跨国界的人才资源等； 5.人才激励：实验室全力协助申请国家、省、市、区、实验室等各级人才计划、科研项目及相关奖励补贴或荣誉称号； 6.生活关怀：按照深圳市及实验室规定，协助办理落户、申请公租房和子女入园/学等事宜。 1.Salary will be commensurate with qualifications and experience, ranging from RMB 120,000-160,000/year for Bachelor's/Master's students and RMB 350,000-390,000/year for PhDs. The initial term will be three years. The contract can be renewed by mutual agreement. 2.Payment of five insurance and one gold according to the upper limit of the contribution ratio in Shenzhen, enjoying national statutory holidays, paid annual leave and other vacations, enjoying Shenzhen Bay Laboratory meal subsidies, holiday sympathy and other benefits. 3.Annual health checkup for employees, supplemental medical insurance, free shuttle bus, employee activities, holiday sympathy, etc. 4.Research environment: provide international standard research conditions and working environment, including sufficient research funding, cutting-edge technology support platform, and cross-border human resources. 5.SZBL makes every effort to assist in applying for national, provincial, municipal, district, laboratory and other levels of talent programs, scientific research projects and related incentives and subsidies or honorary titles. 6.In accordance with the provisions of the Shenzhen Municipality and the laboratory to assist in the settlement, application for public housing and children into the park / school and other matters.