任职要求:
最低一篇中科院2区的第一作者文章
导师简介:
姓名:陈疾忤
学科:骨科运动医学科
行政任职:上海市第一人民医院(上海交通大学医学院附属第一人民医院)
骨科中心副主任、运动医学科主任、外科教研室主任
电子邮箱:jeevechen@gmail.com
个人简介(300字以内):陈疾忤,主任医师,博士生导师,上海交通大学附属第一人民医院骨科运动医学科主任。长期从事运动损伤与软组织修复研究,临床方向聚焦肩、膝、髋等关节镜治疗,基础研究围绕骨骼肌纤维化、巨大肩袖撕裂退变及前交叉韧带重建后的腱骨愈合机制,形成临床与转化研究并重的体系。主持5项国家自然科学基金项目,具备稳定的科研平台与团队基础。近五年在American Journal of Sports Medicine、Arthroscopy、Knee Surg Sports Traumatol Arthrosc、Bioactive Materials等国际期刊发表论文50余篇,并参与多部国际手术指南及图谱编写,多次在ISAKOS、APKASS等国际会议进行大会发言与手术演示。课题组与牛津大学纳菲尔德骨科中心、纽约特种外科医院等保持长期合作,具备国际联合科研与多学科交叉研究能力。
主要研究方向:运动损伤与软组织修复研究,运动损伤的关节镜与康复治疗
主要学术任职(5个以内):中华医学会运动医疗分会全国委员,中国医学救援学会运动伤害分会理事会副会长,中国医师学会运动医学分会膝关节学组副组长,ISAKOS肩关节委员会委员,上海市医学会运动医学专科分会候任主任委员
主持科研项目(省部级和国家级):
1.国家自然科学基金委员会,面上项目,823724491,受M2a型巨噬细胞激活Integrin/FAK/SP1轴的RSPO3高表达成纤维细胞在肩关节僵硬中的作用与机制研究,2025.01-2027.12,49万元,在研,主持。
2.国家自然科学基金委员会,面上项目,82172509,力学相关通路FAK/Smad1通过Irx5调控成纤维成脂前体细胞过度激活促进巨大肩袖撕裂后脂肪浸润的机制研究,2022.01-2024.12,55万元,已结题,主持。
3.国家自然科学基金委员会,面上项目,81972062,成肌细胞外泌体对巨噬细胞极化的影响在骨骼肌钝挫伤后纤维化发生中的作用,2021.01-2023.12,55万元,已结题,主持。
4.国家自然科学基金委员会,面上项目,81772419,骨骼肌损伤纤维化中差异表达LncRNA的筛选及其功能与机制研究,2018.01-2021.12,55万元,已结题,主持。
5.国家自然科学基金委员会,面上项目,82172509,miRNA和TGF-β/SMAD信号通路的相关作用调节骨骼肌损伤后纤维化,2016.01-2018.12,72万元,已结题,主持。
代表性论著(10篇以内):
1)Antioxidant RuCo nanosheet attenuates capsule fibrosis in adhesive capsulitis of shoulder by p38 MAPK signaling pathway inhibition. Mater Today Bio. 2025.(最后通讯)
2)Janus piezoelectric adhesives regulate macrophage TRPV1/Ca2+/cAMP axis to stimulate tendon-to-bone healing by multi-omics analysis. Bioact Mater. 2025.(最后通讯)
3)Regional-specific decellularized meniscus extracellular matrix elastic nanofiber aerogels regulate meniscal regeneration and vascularization. Adv Healthc Mater. 2025.(最后通讯)
4)Agomir-122-loaded nanoparticles coated with cell membrane of activated fibroblasts to treat frozen shoulder based on homologous targeting. J Nanobiotechnology. 2024.(最后通讯)
5)Anterior cruciate ligament femoral footprint is oblong-ovate, triangular, or two-tears shaped in healthy young adults: three-dimensional MRI analysis. Knee Surg Sports Traumatol Arthrosc, 2023.(最后通讯)
6)si-Tgfbr1-loading liposomes inhibit shoulder capsule fibrosis via mimicking the protective function of exosomes from patients with adhesive capsulitis. Biomater Res, 2022.(最后通讯)
7)Engineering bioactive M2 macrophage-polarized, anti-inflammatory, miRNA-based liposomes for functional muscle repair: from exosomal mechanisms to biomaterials. Small, 2022.(最后通讯)
8)Human bone marrow mesenchymal stem cell-derived extracellular vesicles inhibit shoulder stiffness via let-7a/Tgfbr1 axis. Bioact Mater, 2022.(最后通讯)
9)Evaluation of Cam deformity on 3-dimensional computed tomography with the best-fit sphere technique and the alpha angle marking method. Am J Sports Med, 2021.(最后通讯)
10)Preoperative lymphocyte to monocyte ratio can be a prognostic factor in arthroscopic repair of small to large rotator cuff tears. Am J Sports Med, 2020.(最后通讯)
11)Maturity progression of the entire anterior cruciate ligament graft of insertion-preserved hamstring tendons by 5 years: a prospective randomized controlled study based on magnetic resonance imaging evaluation. Am J Sports Med, 2020.(最后通讯)
12)Location of the suture anchor in Hill-Sachs lesion could influence glenohumeral cartilage quality and limit range of motion after arthroscopic Bankart repair and remplissage. Am J Sports Med, 2020.(最后通讯)
13)A synthetic graft with multilayered co-electrospinning nanoscaffolds for bridging massive rotator cuff tear in a rat model. Am J Sports Med, 2020.(最后通讯)
14)Tendon healing progression evaluated with magnetic resonance imaging signal intensity and its correlation with clinical outcomes within 1 year after rotator cuff repair with the suture-bridge technique. Am J Sports Med, 2020.(最后通讯)
15)Morphological changes of the femoral tunnel and their correlation with hamstring tendon autograft maturation up to 2 years after anterior cruciate ligament reconstruction using femoral cortical suspension. Am J Sports Med, 2020.(最后通讯)
16)Stem cell-conditioned medium promotes graft remodeling of midsubstance and intratunnel incorporation after anterior cruciate ligament reconstruction in a rat model. Am J Sports Med, 2019.(最后通讯)
17)Advantages of an attached semitendinosus tendon graft in anterior cruciate ligament reconstruction in a rabbit model. Am J Sports Med, 2018.(最后通讯)
18)Time from injury to surgery affects graft maturation following posterior cruciate ligament reconstruction with remnant preservation: a magnetic resonance imaging-based study. Arthroscopy, 2018.(最后通讯)
19)A randomized clinical trial to evaluate attached hamstring anterior cruciate ligament graft maturity with magnetic resonance imaging. Am J Sports Med, 2018.(最后通讯)
主要荣誉(5个以内):
8、上海市第一人民医院院长奖(医疗奖),上海市第一人民医院,2022
9、旅行学者奖(参访美国著名肩关节外科中心),美国肩肘外科医师协会/中国医药教育促进学会肩肘外科医师委员会,2019
10、医学科技奖二等奖,运动损伤修复重建关键技术建立与应用,中华医学会,2019
11、旅行学者奖(参访美国著名运动医学中心),美国骨科运动医学学会/亚太骨科运动医学学会,2012
中国科技协会三等奖,中国科技协会,黄芪丹参注射液促进骨骼肌损伤修复,2011